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diagnosis hematology differential purpura obstetrics aflp algorithm comparison dermatology hellp intravascular management nonpalpable obgyn palpable pregnancy table anemia ascorbicacid blanching
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
(DIC) Overview ... transfusion • Thrombocytopenia ... : • Petechiae ... Treat primary cause ... #diagnosis #causes
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... hemostasis: - Thrombocytopenia ... fulminans - DIC ... Complete blood count coagulation ... Diagnosis #Algorithm #Causes
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
Thrombocytopenia ... presents with coagulation ... schistocytes, DIC ... child * Severe cases ... #Pregnancy #TTPHUS
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
Thrombocytopenia ... presents with coagulation ... schistocytes, DIC ... child * Severe cases ... #TTPHUS #HELLP
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... • Idiopathic thrombocytopenic ... intravascular coagulation ... (DIC) • Anti-coagulation ... Diagnosis #Algorithm #Causes
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
inflammation • Thrombocytopenia ... : - Thrombocytopenia ... marrow disease - DIC ... Defects: • DIC ... Purpura Fulminans (DIC
Causes of Purpura - Differential Diagnosis Non-PalpabIe → Palpable • Thrombocytopenia (HIT, ITP/HUS), Coagulation defects (DIC, warfarin
Causes of Purpura ... → Palpable • Thrombocytopenia ... HIT, ITP/HUS), Coagulation ... defects (DIC, warfarin ... nonpalpable #palpable #Causes
Bleeding manifestations Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
individuals with thrombocytopenia ... ecchymosis) is caused ... are typical of coagulation ... Measurement of coagulation ... Bruise #ecchymosis #thrombocytopenia
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... intravascular coagulation ... (DIC) - HELLP ... microangiopathy: Thrombotic thrombocytopenic ... Extravascular #Causes
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... reduced, i.e. thrombocytopenia ... purpura - DIC ... intravascular coagulation ... Purpura #Bruising #Causes
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