11 results
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
vascular disorders, coagulation ... inflammation • Thrombocytopenia ... Platelet defects • Coagulation ... : - Thrombocytopenia ... Kasabach-Merritt syndrome Coagulation
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm
Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... purpura (ITP) ... purpura (TTP) ... intravascular coagulation ... (DIC) • Anti-coagulation
Causes of Purpura - Differential Diagnosis
Non-PalpabIe → Palpable
 • Thrombocytopenia (HIT, ITP/HUS), Coagulation defects (DIC, warfarin
Causes of Purpura ... → Palpable • Thrombocytopenia ... HIT, ITP/HUS), Coagulation ... BrighamChiefs #Purpura ... nonpalpable #palpable #Causes
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
transfusion • Thrombocytopenia ... Petechiae • Purpura ... Hemorrhagic bullae • Purpura ... Treat primary cause ... #diagnosis #causes
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Thrombocytopenia ... presents with coagulation ... child * Severe cases ... pregnancy * Severe coagulation ... #Pregnancy #TTPHUS
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
Thrombocytopenia ... presents with coagulation ... child * Severe cases ... pregnancy * Severe coagulation ... #TTPHUS #HELLP
Causes of Purpura or Easy Bruising in Children

Platelet count reduced, i.e. thrombocytopenia
 - Increased platelet destruction
Causes of Purpura ... purpura ... intravascular coagulation ... Henoch—Schönlein purpura ... #Bruising #Causes
Bleeding manifestations 
Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
individuals with thrombocytopenia ... ecchymosis) is caused ... are typical of coagulation ... Measurement of coagulation ... Bruise #ecchymosis #thrombocytopenia
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... intravascular coagulation ... microangiopathy: Thrombotic thrombocytopenic ... purpura (TTP), ... Extravascular #Causes
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... hemostasis: - Thrombocytopenia ... Henoch Schonlein Purpura ... Non-Palpable Rash: - Purpura ... Complete blood count coagulation