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Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
Involvement in Systemic Lupus ... Renal #diseases #SLE ... #Systemic #Lupus ... nephrology #nephritis #classification ... #types #rheumatology
Lupus Classification
Spontaneous Lupus
 - Cutaneous Lupus Erythematosus (CLE)
 - Systemic Lupus Erythematosus 
Drug-Induced Lupus
 - Drug-Induced
Lupus Classification ... Erythematosus (CLE ... (SCLE-DIL) - ... #Classification ... erythematosus #rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... pericarditis • Hematologic ... #EULARACR #Classification ... #Criteria #SLE ... Erythematosus #diagnosis #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... life-threatening • Treatment ... #lupus #Systemic ... Management #Summary #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Puncture, EEG Treatment ... Erythematosus #SLE ... CNS #neurology #rheumatology ... diagnosis #management #treatment
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... • Specific for SLE ... severe disease Treatment ... #Systemic #Lupus ... Summary #diagnosis #rheumatology
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
in 10 to 40% of SLE ... severity (ISN/RPS classification ... by 12 months Classification ... Nephritis #Management #treatment ... #management #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
vs SLE Drug Induced ... constitutional symptoms • Treatment ... Erythematosus (SLE ... life-threatening • Treatment ... #table #rheumatology
Cutaneous Lupus Erythematosus
 • Acute Cutaneous Lupus (ACLE)
 • Neutrophilic Dermatoses 
 • Vascular Lesions
 •
Cutaneous Lupus ... Acute Cutaneous Lupus ... (SCLE) • Intermittent ... #types #venn #rheumatology ... #classification
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Immunotactoid GN ... -C3 GN • Cast ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology