14 results
Approach to managing Glomerulonephritis (GN) in children. 

ANCA, antineutrophil cytoplasmic antibodies; c-ANCA, cytoplasmic antineutrophil cytoplasmic antibodies;
Glomerulonephritis (GN ... antibodies; GBM, glomerular ... SLE, systemic lupus
Rapidly Progressive Glomerulonephritis (RPGN) 
 - Loss of kidney function over a short period of tirne
with evidence of glomerular ... immune deposits in glomeruli ... IgA nephropathy, lupus ... post-infectious GN ... Anti-Glomerular
Summary of characteristic abnormalities of selected glomerular diseases
Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
abnormalities of selected glomerular ... /nephritis • Lupus ... Post-infectious GN ... • Membranous GN ... pathology #comparison #table
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... diagnosis #algorithm #rheumatology
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... glycoprotein I (ß2GP), Lupus ... Autoantibodies #Rheumatology ... #associations #table
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
Management of Lupus ... Nephritis Lupus ... Focal LN (<50% of glomeruli ... Diffuse LN (>50% of glomeruli ... treatment #management #rheumatology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework
Prerenal:
 • Due to true volume loss or decreased
damage to the glomeruli ... some abx, heme pigment ... nephritis) • GN
Connective tissue disease-associated interstitial lung diseases

LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
SLE : systemic lupus ... Differential #Comparison #Table ... #Pulmonary #Rheumatology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Immunotactoid GN ... Cryoglobulinemic GN ... -C3 GN • Cast ... to cold IgG • Lupus ... Paraproteinemias #Hematology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
antibodies and Systemic lupus ... Farr assay) and lupus ... & drug-induced lupus ... erythematosus #diagnosis #rheumatology ... #table #ANA