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diagnosis hematology causes algorithm ana erythematosus systemic workup management sle anemia arthritis nephrology vasculitis autoantibodies classification dermatology glomerulonephritis hemolytic joint
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... Kumfer @AnnKumfer #Antinuclear ... #Antibodies #ANA ... #patterns #rheumatology ... #diagnosis #differential
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... Kumfer @AnnKumfer #Antinuclear ... #patterns #rheumatology ... #diagnosis #differential
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... Antineutrophil cytoplasmic antibodies ... ) • Systemic lupus ... Antineutrophil #antibodies ... #diagnosis #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... Purpura Anti-GBM antibodies ... involvement: Anti-GBM Disease ... diagnosis #algorithm #rheumatology
I’M DAMN SHARP - Lupus Diagnosis Mnemonic I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid) M Malar Rash D
M DAMN SHARP - Lupus ... Discoid Rash A Antinuclear ... Arthritis R Renal Disease ... sle #systemic #lupus ... erythematosus #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... Association with disease ... with auto-immune diseases ... Lupusreference #Antinuclear ... erythematosus #diagnosis #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
SLE-Related Auto-Antibodies ... (aPL) 30-45% Differential ... auto-immune, Infectious diseases ... sclerosis, Still's disease ... #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... - Summary Antinuclear ... with more severe disease ... #Systemic #Lupus ... Summary #diagnosis #rheumatology
Sensitivity of the ANA in Autoimmune & Nonrheumatic Disease #Diagnosis #Rheumatology #ANA #AntiNuclear #Antibodies #Sensitivity
& Nonrheumatic Disease ... #Diagnosis #Rheumatology ... #ANA #AntiNuclear ... #Antibodies #Sensitivity
Common causes of Acute Kidney Injury AKI - Differential Diagnosis HEMODYNAMIC • Cardiac failure: Impaired forward flow,
Kidney Injury AKI - Differential ... • Primary GNs: Disease ... Due to systemic disease ... Post-infectious GN ... , Lupus Acute Tubular
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