14 results
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in ... Rheumatology • ... Lupus (SLE): ANA ... glycoprotein I (ß2GP), Lupus ... #Rheumatology #
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms ... constitutional symptoms ... of autoantibodies ... #sle #comparison ... #table #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... the formation of autoantibodies ... Erythematosus #SLE ... #CNS #neurology ... #rheumatology #
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Auto-Antibodies: - ANA ... Lupusreference #SLE ... Erythematosus #Diagnosis #autoantibodies ... #signs #symptoms ... #differential #rheumatology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Systemic lupus ... lupus nephritis ... , neonatal lupus ... #Antinuclear #autoantibodies ... erythematosus #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... • Anti-Ro/SSA autoantibodies ... Non-autoimmune rheumatologic ... : • Symptoms limited ... Erythematosus #Diagnosis #Rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... erythematosus (SLE ... erythematosus (SLE ... (SLE), Systemic ... #patterns #rheumatology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Amyloidosis and ... histiocytosis, and ... macular Vasculitis) Autoantibodies ... to cold IgG • Lupus ... Paraproteinemias #Hematology
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
Management of Lupus ... Nephritis Lupus ... in 10 to 40% of SLE ... treatment #management #rheumatology ... #nephrology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Rapidly progressing GN ... diseases, such as SLE ... Presentation: Systemic Symptoms ... • Progressive symptoms ... Differential #Diagnosis #Rheumatology