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diagnosis differential antinuclear autoantibodies classification erythematosus glomerulonephritis hematology sle vasculitis workup anca antineutrophil antiphospholipid apls arthritis associations criteria disease diseases
Approach to managing Glomerulonephritis (GN) in children. ANCA, antineutrophil cytoplasmic antibodies; c-ANCA, cytoplasmic antineutrophil cytoplasmic antibodies;
Glomerulonephritis (GN ... cytoplasmic antibodies ... ; SLE, systemic ... lupus erythematosus ... Glomerulonephritis #Algorithm
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... antibody), dsDNA ... others (RNP, aPL antibodies ... • Scleroderma (Systemic
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Classification Criteria for Systemic ... low C4, Low C3 and ... Highly specific antibodies ... Criteria #SLE #Systemic ... #diagnosis #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antibody) and ANCA ... ) • Systemic lupus ... drug-induced SLE) • Systemic ... #antibodies #diagnosis ... #rheumatology #
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers ... to antibodies against ... #Antinuclear #Antibodies ... #rheumatology #diagnosis
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Inflammatory and ... Autoimmune Diseases: • Systemic ... lupus erythematosus ... hemoglobinuria • Antibody-mediated ... • Epstein-Barr virus
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... Purpura Anti-GBM antibodies ... differential #diagnosis #algorithm ... #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... SLE-Related Auto-Antibodies ... : - ANA 95-100% ... autoantibodies #signs ... #differential #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... lupus erythematosus ... purpura: strong sign ... ) pattern: antibodies ... differential #diagnosis #rheumatology
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Hypercoagulable Workup Algorithm ... excluded Testing: • Lupus ... • Prothrombin Antibody ... Hypercoagulable #Workup #Algorithm ... #diagnosis #hematology
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