12 results
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
- Differential Diagnosis ... capillary leak syndrome ... • Schnitzler syndrome ... Cryoglobulinemia Renal-centered ... #hematology #oncology
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
Regulating Renal ... • Diagnosis of ... Tolvaptan) • Treatment ... #Renal #Excretion ... #Pharmacology #
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
plasma insulin (treatment ... Villous adenoma Renal ... (carbonic anhydrase ... chewing tobacco, Renal ... #differential #diagnosis
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
tubulopathy • Monoclonal ... gammopathy of renal ... malignancies Treatment ... #AKI #Cancer #Oncology ... #Differential #Diagnosis
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
: Differential Diagnosis ... acute reversal of chronic ... after renal tubule ... markedly reduced GFR ... #Differential #Diagnosis
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Can Feature A Monoclonal ... Amyloidosis and monoclonal ... vascular beds-renal ... #Differential #Diagnosis ... #Oncology
Thiamine Deficiency - Differential Diagnosis Framework and Clinical Manifestations

Causes of Thiamine Deficiency:
 • Poor intake:
	- Diets
- Differential Diagnosis ... processed grains - Chronic ... gravidarum - Diuretic ... - Chronic neurological ... - Decreased GFR
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Anaphylaxis, Acute Renal ... Supportive Care: Diuresis ... management #hematology #oncology
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
Hepatorenal Syndrome ... perfusion + ↑ renal ... dominates → ↓ GFR ... Treatment Overview ... #Hepatorenal #Syndrome
Secondary Causes of Hyperlipidemia
Nunerous secondary causes of hyperlipidemia exist; screening for the presence of these underlying
Diabetes mellitus, Chronic ... renal failure, ... beta-blockers, diuretics ... Hypothyroidism, Nephrotic syndrome ... #differential #diagnosis