38 results
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
central nervous system ... and less common diseases ... diagnosis and treatment ... • Systemic lupus ... #neurology #inflammatory
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
Differential Diagnosis Algorithm ... arthritis - (Reiter’s syndrome ... Lupus - with Systemic ... Lupus Erythematosus ... like “butterfly rash
Mucous Membrane Disorder - Differential Diagnosis Algorithm
Erosions/Ulcers/Blisters
 - Primary Dermatologic Diseases
     •
Differential Diagnosis Algorithm ... Stevens-Johnson Syndrome ... necrolysis - Systemic ... Systemic lupus ... • Behcet's syndrome
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... block • Sjogren syndrome ... polymyositis overlap syndrome ... Treatment: • ... #Lupus #Erythematosus
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... Demyelinating Syndrome ... Cerebrovascular Disease ... Puncture, EEG Treatment ... #SLE #CNS #neurology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Lupus (SLE) General ... Photosensitivity, Butterfly rash ... Demyelinating syndromes ... pain (20%) Renal disease ... Thrombocytopenia #Lupus
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation Syndrome ... • Systemic lupus ... Petechial or purpuric rash ... lupus erythematosus ... Treatment: • Corticosteroids
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Manifestations: Malar rash ... life-threatening • Treatment ... Evolution: Chronic disease ... #Systemic #Erythematosus
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Joint Pain Rash ... infection Malar rash ... PAN Pyoderma gangrenosum ... Antiphospholipid-antibody syndrome ... lesions • Discoid lupus
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal Syndrome ... Immune Complex: Systemic ... lupus erythematosus ... Rheumatoid arthritis, Systemic ... differential #diagnosis #nephrology