23 results
diagnosis differential anemia algorithm causes blood rbc atlas extravascular hemolytic intravascular management mcv microscopy morphology pharmacology product reactions rheumatology thrombocytosis
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
fragmentation hemolysis ... • Severe B12 deficiency ... • Mechanical hemolysis ... differential #diagnosis #hematology ... #hemolysis
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis ... and RES-mediated hemolysis ... Defects • G6PD deficiency ... • PK deficiency ... Algorithm #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Intravascular Hemolysis ... Microangiopathic hemolytic ... G6PD deficiency) ... differential #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... ' nucleotidase deficiency ... elliptocytosis, autoimmune hemolysis ... ARUPConsult @ARUPLabs #Hemolytic ... Algorithm #workup #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Diseases: • GATA2 deficiency ... Antibody-mediated hemolysis ... B12 • Folate deficiency ... Differential #Diagnosis #Hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
inflammation) • Iron deficiency ... -100): • Non-hemolytic ... anemia, CKD • Hemolytic ... , B12 deficiency ... Differential #Diagnosis #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Bleed • Hemolysis ... Microangiopathic Hemolytic ... • Early Iron Deficiency ... Algorithm #Causes #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
80 fL) • Iron Deficiency ... • Bleeding • Hemolysis ... 100 fL) • B12 Deficiency ... • Folate Deficiency ... Algorithm #Causes #Hematology
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Microangiopathic hemolytic ... Microspherocytes: Autoimmune hemolytic ... Bite cells: G6PD deficiency ... Smear #Analysis #hematology
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Iron Deficiency ... extravascular) hemolysis ... Zinc excess or deficiency ... , Copper deficiency ... Algorithm #ferritin #hematology
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