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diagnosis symptoms signs management differential endocrinology cardiology clinical pharmacology nephrology syndrome peds pediatrics algorithm causes infectiousdiseases ophthalmology msk complications lifecycle
Synthesis, metabolism and functions of vitamin D. PTH parathyroid hormone, FGF-23 fibroblast growth factor-23, RANKL receptor
-23 fibroblast growth ... VitaminD #Metabolism #Pathophysiology
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
Growth Hormone Excess ... share the same pathophysiology ... excess prior to growth ... GH excess after growth ... endocrinology #pathophysiology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Feedback Loop: Growth ... Hormone (GH) Growth ... pathway -> Incr cell growth ... endocrinology #pathophysiology
Lung Microbiome - The dysbiosis-inflammation cycle. Inflammation of the airways alters environmental growth conditions of airway
environmental growth ... Disordered growth ... inflammation #cycle #pathophysiology
Melanoma Pathogenesis Environmental exposure (UV light) + genetic susceptibility (CDKN2A, CDK4, MC1R, BRAF, p16/ARF genes) → accumulation
, blood vessel growth ... #Pathophysiology
The pathogenesis of idiopathic pulmonary fibrosis. 1 – In an initiating phase, there is lung alveolar
platelet derived growth ... platelet-derived growth ... = transforming growth ... vascular endothelial growth ... #IPF #Pathophysiology
Menstrual Cycle Physiology: Ovarian Cycle – Follicular Phase Explained Early Follicular Phase (Days 0-5) • Granulosa cells
stimulates follicle growth ... follicle still grows ... normal follicle growth ... lack of follicle growth ... #OvarianCycle #pathophysiology
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
Osteoblasts and Growth ... #Osteoporosis #pathophysiology
Menstrual Cycle Physiology: Ovarian Cycle – Brief Overview LH and FSH are required for follicular development and
and continued growth ... #OvarianCycle #pathophysiology
Melanoma tumour progression (based on the Clark model) - Benign melanocytic nevi: controlled proliferation of normal
nevi: abnormal growth ... - Radial growth ... - Vertical growth ... #Pathophysiology
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