68 results
Kaposi Sarcoma Herpes Virus (KSHV)

By Dr. Sara Dong @swinndong via #IDFellowCase
#ID  #Infectious Diseases  #Infections
#Differential
ID #Infectious Diseases ... Diagnosis #KSHV #HHV ... lymphoproliferative #KICS
Clinical Manifestations of Human Herpes Viruses (HHV)

Herpes simplex virus 1	HSV-1	Frequently subclinical (80-90%) Oral lesions (10-20%) congenital
Herpes Viruses (HHV ... Mononucleosis-like disease ... herpes virus 6 HHV ... herpes virus 7 HHV ... Herpes #Viruses #HHV
HHV8/KSHV-reIated diseases: From Cellular Proliferation to Hyperinflammation
Kaposi sarcoma (KS):
 • Target organs: Ubiquitous (cutaneous and mucosal
HHV8/KSHV-reIated ... diseases: From ... Light chain: - HHV8 ... de Fremont #HHV8 ... #diseases #comparison
Castleman's Disease and Associated Syndromes
HYALINE VASCULAR VARIANT
 • unicentric, HHV8-ve, children and young.
 • Hyalinized vessels
Castleman's Disease ... • unicentric, HHV8 ... with Castleman's disease ... Plasmablastic subtype is HHV8 ... myeloma, POEMS) HHV8
KSHV Inflammatory Cytokine Syndrome (KICS)

By Dr. Sara Dong @swinndong  via #IDFellowCase
#ID  #Infectious Diseases
Cytokine Syndrome (KICS ... ID #Infectious Diseases ... Diagnosis #KSHV #HHV ... #KICS #Kaposi
IDSA Recommendations for Preventing and Treating HHV-8 Diseases—Kaposi Sarcoma (KS), Primary Effusion Lymphoma (PEL), Multicentric Castleman’s
Preventing and Treating HHV ... activity against HHV ... recommended for KS treatment ... adjunctive therapy #HHV8 ... IDSA #Prevention #Treatment
Hansen's Disease (Leprosy)
 • Transmission - not completely understood, ?nasal droplets
 • Symptoms appear ~5 years
people do not contract ... factors: Close contact ... chemotherapy, SOT, HIV ... and numerous AFB Treatment ... diagnosis #management #treatment
Pharmacologic treatment algorithms by Global Initiative for Chronic Obstructive Lung Disease grade. Highlighted boxes and arrows
Pharmacologic treatment ... Obstructive Lung Disease ... indicate preferred treatment ... long-acting β2-agonist; ICS ... GOLD2017 #LAMA #LABA #ICS
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... borrelia, Rubeola, HBV ... Coxsackie, CMV, EBV, HIV ... autoinflammatory diseases ... diagnosis #management #treatment
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Virus (EBV, CMV, HHV8 ... • Autoimmune diseases ... Adult-onset Still disease ... Unknown cause Treatment ... diagnosis #management #treatment