14 results
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
Heparin, Fondaparinux ... Anticoagulants - Pathophysiology ... Unfractionated heparin ... #Pharmacology #Pathophysiology ... #Heparins #LMWH
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
aldosterone inhibition (Heparin ... #hyperkalemia #differential ... #diagnosis #pathophysiology ... #pharmacology #
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
Heparin Induced ... ♀, ↑Age, ESRD Pathophysiology ... • IgG binds heparin-PF4 ... • Start non-heparin ... #HIT #Heparin
Mechanism of Action of Bile Acid Sequestrants
Bile Acid Sequestrants → ↓ Hepatic Bile Acid Pool →
Sequestrants → ↓ Hepatic ... Acid Pool → ↑ Hepatic ... sequestration #pathophysiology ... #pharmacology #
Drugs that Impair Renal Potassium Excretion 

Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine
Decreased Aldosterone Synthesis: Heparin,
Aldosterone Synthesis: Heparin ... #Hyperkalemia #Pathophysiology ... #Pharmacology #
Lactulose: Mechanism of Action in Hepatic Encephalopathy
Lactulose → ↑ Lactic Acid, Acetic Acid → ↓ pH
Mechanism of Action in Hepatic ... #Lactulose #pharmacology ... ammonia #hepatology #pathophysiology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
protein C and S Pathophysiology ... dysfunction (25%) • Hepatic ... deficiency) • HIT ... : Heparin-PF4 antibodies ... 100mg/dL) - Heparin
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Arterial Thrombosis - Differential ... Hematological: - HIT ... Hyperhomocysteinemia - Heparin-induced ... Venous #Arterial #pathophysiology ... #hematology #differential
Schematic representation of the major sources of ammonia production and its excretory pathway (GI = gastrointestinal,
that although hepatic ... also many non-hepatic ... = Non hepatic ... deficiency #Ammonia #Pathophysiology ... Hyperammonemia #Differential
Causes of B12 deficiency. 

This great diagram shows normal absorption and outlines most possible causes. At
B12-deficient diet ... VitaminB12 #deficiency #Differential ... Causes #Diagnosis #Pathophysiology