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causes injury liver thrombocytosis adultonset aplastic apml chronic classification differentiation diffuse dili disease druginduced fatigue gap globulin hepatitis hodgkins lad
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Diagnosis Algorithm ... Infectious: • Acute ... Iron deficiency anemia ... #Diagnosis #Algorithm ... #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Diagnosis Algorithm ... → Refer to hematology ... , deficiency anemia ... #Diagnosis #Algorithm ... #hematology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... , HBV, HCV, HEV, ... Cholestatic: Benign/malignant ... dechallenge • Acute ... #Algorithm #hepatology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Diagnosis Algorithm ... • CMV • HIV ... #Diagnosis #Algorithm ... #Causes #Hematology ... #Oncology
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
fraction < 20% Differential ... borrelia, Rubeola, HBV ... , HIV, HTLVI, Hantavirus ... #management #treatment ... #rheumatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Liver Injury - Differential ... Diagnosis Hepatocellular ... , CMV, HSV • Toxic ... #Acute #algorithm ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Diagnosis Algorithm ... , HBV, HCV, HEV, ... EBV, HSV, CMV, ... diagnosis #algorithm ... #hepatology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Diagnosis Algorithm ... • Anemia • ... Malignancy Infectious ... • HIV Autoimmune ... #Diagnosis #Algorithm
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
- CMV - HCV ... - HIV • Immune ... immunodeficiency virus (HIV ... #oncology #hematology ... #diagnosis #management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... initiation • Differential ... • Steroids: IV ... #management #hematology ... #oncology
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