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diagnosis algorithm causes management oncology pathophysiology thrombocytosis aplastic arterial calculation cancer embolism fatty ferritin folate folicacid hyponatremia index iron lfts
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Thrombocytosis - Differential ... Inflammatory: • IBD ... malignancy • Iron deficiency ... anemia #Thrombocytosis ... Algorithm #Causes #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
= (Retic %) x (Hct ... deficiencies: Iron deficiency ... , G6PD deficiency ... Production #Index #hematology ... #anemia #differential
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... → Refer to hematology ... Acute hemolysis, deficiency ... anemia, Rebound ... Diagnosis #Algorithm #hematology
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Iron Deficiency ... Anemia - Differential ... Tropical sprue, IBD ... #Anemia #Differential ... Algorithm #ferritin #hematology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Liver Enzymes - Differential ... • Pregnancy - AFLP ... NAFLD • Others Mild ... • AIH • A1AT deficiency ... Others #LFTs #Hepatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... , GATA2 deficiency ... , CTLA4 deficiency ... • Allogeneic HSCT ... #oncology #hematology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... AP, ↑INR, ↑BUN/Cr ... ↓Antithrombin Ill ... infiltration) Differential ... Liver #Pregnancy #hepatology
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
have hemolytic anemia ... with underlying mild ... folate deficiency ... #FolicAcid #differential ... #diagnosis #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Arterial Thrombosis - Differential ... contraceptives - HRT ... Ischemic Liver, IBD ... pathophysiology #hematology ... #differential #
Hyponatremia Differential Diagnosis Algorithm in Cancer UOsm ≥ 100 mOsm/kg = Urine is inappropriately concentrated for hypotonic
Hyponatremia Differential ... - and IL-2- induced ... VOD following HSCT ... • Cortisol deficiency ... isolated ACTH deficiency
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