21 results
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework

STRUCTURAL:
 - PFO: paradoxical emboli
 - Popliteal
Causes of Arterial ... - Differential ... artery aneurysm: Causes ... Lipoprotein a ↑ - IBD ... Diagnosis #clots #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
- Differential ... contraceptives - HRT ... Ischemic Liver, IBD ... pathophysiology #hematology ... #differential #
Erythrocytosis - Polycythemia Differential Diagnosis Algorithm

Elevated Hemoglobin:
 • Males: Hb > 16.5 g/dL/HCT ≥ 49%
 •
- Polycythemia Differential ... Hb > 16.5 g/dL/HCT ... : Hb > 16 g/dL/HCT ... Polycythemia - Acquired Causes ... Diagnosis #Algorithm #hematology
Causes of Breakthrough/Extension of Thrombosis and Management Algorithm

#Anticoagulation #Breakthrough #Thrombosis #Algorithm #Extension #VTE #DVT #Hematology #Management
Causes of Breakthrough ... and Management ... Extension #VTE #DVT #Hematology ... #Differential # ... Causes
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Liver Enzymes - Differential ... NAFLD • Others Mild ... • Pancreatic cancer ... Others #LFTs #Hepatology ... Diagnosis #Algorithm #Causes
Portal Vein Thrombosis (PVT) Treatment Algorithm
 - If concern for ischemic: anti-coag+multidisciplinary care
 - W/o cirrhosis+recent
Portal Vein Thrombosis ... Algorithm - If concern ... - Cirrhosis: case-by-cased ... PVT #Treatment #management ... #Algorithm #hepatology
Thrombotic Microangiopathy - TMAs
1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
Thrombotic Microangiopathy ... almost) all TMAs cause ... Cr>2.3 & platelets ... APS, SRC, SLE), cancer ... Microangiopathy #TMAs #hematology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
= nonspecific (nausea ... AP, ↑INR, ↑BUN/Cr ... ↓Antithrombin Ill ... infiltration) Differential ... Liver #Pregnancy #hepatology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
= (Retic %) x (Hct ... infiltration (e.g. cancer ... Production #Index #hematology ... #anemia #differential
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
cytokines (TNFa,lL1, IL6 ... B-LNH), solid cancers ... Drugs, Unknown cause ... PTLD), allogeneic HSCT ... Lymphohistiocytosis #diagnosis #management