Haglund syndrome rheumatology workup ucl autoantibodies diseases systemic antinuclear hematology erythematosus signs antibody lupus vasculitis disease treatment cryoglobulins

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ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
• Systemic lupus erythematosus
1. Anti-dsDNA

lupus erythematosus ... connective tissue disease ... 90% • Anti-GBM disease ... antibodies #diagnosis #rheumatology ... #diseases

Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like

or Anti-NucIear Antibody ... lupus erythematosus ... lupus erythematosus ... lupus erythematosus ... ANA #patterns #rheumatology

Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
• Associated

Systemic Lupus Erythematosus ... - Summary Antinuclear ... Treatment: • ... #Lupus #Erythematosus ... Summary #diagnosis #rheumatology

Cryoglobulinemia Summary

Cryoglobulins:
• Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below

activate the immune system ... • Autoimmune diseases ... Antineutrophil cytoplasmic antibody ... lupus erythematosus ... classification #rheumatology

CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic

Lupus Erythematosus ... Demyelinating Syndrome ... Cerebrovascular Disease ... #Lupus #Erythematosus ... CNS #neurology #rheumatology

SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and

SLE (Systemic Lupus ... Decade Skin Disease ... diseases (i.e. ... ) • Kikuchi disease ... #Diagnosis #Rheumatology

Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin

Butterfly rash, Vasculitis ... pain (20%) Renal disease ... #erythematosus # ... signs #symptoms ... #diagnosis #rheumatology

Antinuclear antibodies and Systemic lupus
Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can

and Systemic lupus ... Association with disease ... with auto-immune diseases ... #Systemic #lupus ... #diagnosis #rheumatology

Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
•

(Granulomatous disease ... rheumatic diseases ... lupus erythematosus ... atherosclerotic disease ... differential #diagnosis #rheumatology

IgG4-Related Disease
Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
•

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