Haglund syndrome rheumatology workup ucl autoantibodies diseases systemic disease antibodies antibody antinuclear lupus diagnosis associations myositis

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Autoantibodies in Rheumatology
• Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and

Autoantibodies in ... others (RNP, aPL antibodies ... Peptide (CCP) • Myositis ... • Scleroderma (Systemic ... diagnosis #associations

Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA

their Disease Associations ... connective tissue disease ... (TTG) - Celiac disease ... diseases #diagnosis ... #antibodies

Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like

Antinuclear Antibodies ... or Anti-NucIear Antibody ... : Lupus (SLE), Systemic ... , Myositis, Mixed ... #patterns #rheumatology

ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
• Systemic lupus erythematosus
1. Anti-dsDNA

) • Systemic lupus ... connective tissue disease ... 90% • Anti-GBM disease ... #diagnosis #rheumatology ... #diseases

ANA Patterns and Associated Rheumatic Diseases:
• Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease

Associated Rheumatic Diseases ... connective tissue disease ... SLE), Sjogren's Syndrome ... #Antibodies #ANA ... #patterns #rheumatology

I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M Malar Rash
D

Discoid Rash A Antinuclear ... Antibody (ANA) ... Arthritis R Renal Disease ... IMDAMNSHARP #sle #systemic ... #rheumatology #

Antinuclear antibodies and Systemic lupus
Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can

Antinuclear antibodies ... and Systemic lupus ... with disease activity ... with auto-immune diseases ... #Systemic #lupus

Systemic Lupus Erythematosus - Diagnosis
Manifestations:
- Arthritis 69%
- Malar rash 40%
- Fever 36%
-

Systemic Lupus Erythematosus ... anemia 4% - Myositis ... auto-immune, Infectious diseases ... sclerosis, Still's disease ... #Diagnosis #autoantibodies

SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and

SLE (Systemic Lupus ... Decade Skin Disease ... diseases (i.e. ... ) • Kikuchi disease ... #Diagnosis #Rheumatology

IgG4-Related Disease
Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
•

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