Haglund syndrome rheumatology workup ucl autoantibodies diseases systemic disease antibodies table autoimmune ana antibodies antineutrophil erythematosus

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Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA

Autoantibodies and ... their Disease Associations ... (TTG) - Celiac disease ... #Associations #diseases ... antibodies

ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
• Systemic lupus erythematosus
1. Anti-dsDNA

erythematosus ... connective tissue disease ... 90% • Anti-GBM disease ... #rheumatology # ... diseases

Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like

Positive ANA ≠ Autoimmune ... Disease! ... Rheumatic Diseases ... • Rheumatic Diseases ... #rheumatology #diagnosis

ANA Patterns and Associated Rheumatic Diseases:
• Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease

Associated Rheumatic Diseases ... connective tissue disease ... SLE), Sjogren's Syndrome ... #Antinuclear #Antibodies ... #rheumatology #diagnosis

Autoantibodies in Rheumatology
• Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and

Autoantibodies in ... Rheumatology • ... others (RNP, aPL antibodies ... • Scleroderma (Systemic ... #associations #table

SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and

Decade Skin Disease ... tissue disease ... rheumatologic diseases ... (e.g. thyroid disease ... ) • Kikuchi disease

Systemic Lupus Erythematosus - Diagnosis
Manifestations:
- Arthritis 69%
- Malar rash 40%
- Fever 36%
-

Systemic Lupus Erythematosus ... SLE-Related Auto-Antibodies ... : - ANA 95-100% ... auto-immune, Infectious diseases ... sclerosis, Still's disease

Antinuclear antibodies and Systemic lupus
Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can

Antinuclear antibodies ... and Systemic lupus ... Association with disease ... with auto-immune diseases ... #table #ANA

Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease

multisystemic disease ... associated with other diseases ... demyelinating disease ... peripheral Thyroid Disease ... Tracheobronchial disease

IgG4-Related Disease
Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
•

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