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diagnosis sle ana antibodies antinuclear associations classification differential anca antineutrophil comparison cryoglobulinemia cryoglobulins druginduced management monoclonal oncology paraproteinemias symptoms types
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Rheumatology • ... • Scleroderma (Systemic ... Polymerase Ill • ANCA Vasculitis ... #Rheumatology # ... #associations #table
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... Anti-Scl-70 - Scleroderma ... #Autoantibodies ... #diagnosis #table ... #rheumatology #
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
antibodies) • Systemic ... lupus erythematosus ... scleroderma) - Anti-Scl ... cases • Sjögren syndrome ... antibodies #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... • Anti-Ro/SSA autoantibodies ... lupus erythematosus ... #Lupus #Erythematosus ... #Diagnosis #Rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Butterfly rash, Vasculitis ... Demyelinating syndromes ... #erythematosus # ... signs #symptoms ... #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... ischemia - Skin: erythematous ... lupus erythematosus ... purpura: strong sign ... differential #diagnosis #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
SLE-SSc-AlM overlap syndromes ... #Systemic #lupus ... #erythematosus ... #diagnosis #rheumatology ... #table #ANA
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... • Autoimmune diseases ... Antineutrophil cytoplasmic antibody ... lupus erythematosus ... classification #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... ) Autoantibodies ... Evans • ITP • Cl-NH ... to cold IgG • Lupus ... Paraproteinemias #Hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
months to years) Systemic ... Lupus Erythematosus ... Evolution: Chronic disease ... sle #comparison #table ... #rheumatology #
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