21 results
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • Aplastic Anemia ... Leukemia, Tumour ... Non-lmmune: • HELLP Syndrome ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Chronic Myelogenous Leukemia ... effect following treatment ... following EtOH induced thrombocytopenia ... Iron deficiency anemia ... #Causes #Hematology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
• Most common leukemia ... of anemia or thrombocytopenia ... marrow failure with anemia ... or thrombocytopenia ... #oncology #hematology
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Script Signs and symptoms ... Treatment: • Consider ... to MDS or acute leukemia ... diagnosis #management #treatment ... #hematology
Approach to Leukocytosis - Differential Diagnosis Algorithm

Features of hematologic malignancy:
 • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
malignancy: • Symptoms ... : B-symptoms, bruising ... hepatomegaly • Labs: anemia ... #hematology #WBC ... #Leukemoid
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... - infiltrates (anemia ... , thrombocytopenia ... • Tumor lysis syndrome ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
with no early symptoms ... • Neutropenia, anemia ... , thrombocytopenia ... microglobulin Treatment ... • Sezary syndrome
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
infections/fevers • Thrombocytopenia ... virus (EBV) • Leukemia ... Treatment: ... • Improve the symptoms ... #oncology #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... cytopenias (usually anemia ... transformation to acute leukemia ... only curative treatment ... #hematology #oncology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... platelet count (thrombocytopenia ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... IDUS) • Immune Thrombocytopenia