38 results
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
Neutropenia with Pancytopenia ... - Differential ... Diagnosis Algorithm ... Sequestration: • Splenomegaly ... #Causes #Hematology
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
Pancytopenia - Differential ... < 1800/uL, • platelet ... sequestration (splenomegaly ... MatthewHoMD #Pancytopenia ... #hematology #workup
Approach to Leukocytosis - Differential Diagnosis Algorithm

Features of hematologic malignancy:
 • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Diagnosis Algorithm ... B-symptoms, bruising/bleeding ... lymphadenopathy, petechiae, splenomegaly ... anemia, ↑ MCV, ↑/↓ platelets ... #hematology #WBC
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Count - Differential ... Diagnosis Algorithm ... → Refer to hematology ... Vasculitides, IBD, Celiac disease ... #hematology
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
without platelet ... myelofibrosis and splenomegaly ... Defects #comparison #table ... #differential # ... diagnosis #hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... / Bruising - Differential ... Diagnosis Algorithm ... Sequestration Disordered Platelet ... #Causes #Hematology
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
Von Willebrand Disease ... common inherited bleeding ... Laboratory • Normal platelet ... VonWillebrand #Disease ... #Diagnosis #Hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Hemolytic anemia - Splenomegaly ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Disorders - Differential ... Diagnosis and Workup ... - History of bleeding ... ITP, unexplained pancytopenia ... #Workup #hematology
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Pancytopenia - Differential ... Diagnosis Congenital ... Diseases: • GATA2 ... #Differential # ... Diagnosis #Hematology