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diagnosis hematology differential hemolytic autoimmune management agglutinin aiha anemias arteritis bronchiectasis causes comparison disease extravascular gca giantcell intravascular platelets pulmonary
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Signs of anemia ... and hemolysis: ... Immune-mediated Hemolysis ... Nonimmune-mediated Hemolysis
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Hemolytic Anemia ... Spherocytes • Treatment ... Mostly transient hemolysis ... • Treatment: Warm ... #Anemia #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis ... and RES-mediated hemolysis ... Intravascular - Hemolysis ... anemia • ... malformations #Hemolysis
Autoimmune Hemolytic Anemia (AIHA) Treatment Warm AIHA: 1) Steroids - 1-2 mg/kg prednisone daily • Until
Anemia (AIHA) Treatment ... > 10, no more hemolysis ... azathioprine Cold ... #Anemia #AIHA # ... #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
of anemia include ... anemia • Cold ... • Compensated hemolysis ... intravascular hemolysis ... #anemia #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... Agglutination - Cold ... elliptocytosis, autoimmune hemolysis ... #workup #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Differential Diagnosis Algorithm ... blood loss, Acute hemolysis ... , deficiency anemia ... Rebound effect from treatment ... Inflammatory Conditions: Rheumatologic
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
those coming off aorta ... systemic sx + signs ... systemic complaints- anemia ... Treatment of GCA ... them, but urgent rheumatology
Bronchiectasis - Summary What? • Bronchiectasis is derived from the Greek words bronckos meaning airway and ectasis meaning
inflammation Symptoms ... • Dyspnea • Hemoptysis ... obstruction • COPD ... Nasal polyps and signs ... mycobacteria Treatment
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... < 30 years • Aorta ... pulmonary infiltrates, hemoptysis ... infiltrates/cavities, hemoptysis ... Differential #Diagnosis #Rheumatology
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