41 results
Clinical Manifestations of Systemic Lupus Erythematosus (SLE)

#Systemic #Lupus #Erythematosus #SLE #Manifestations #Signs #Symptoms #Rheumatology #Diagnosis
Manifestations of Systemic Lupus ... ) #Systemic #Lupus ... Manifestations #Signs ... #Symptoms #Rheumatology ... #Diagnosis
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
- Differential Diagnosis ... Algorithm Signs ... of anemia and hemolysis ... #Differential #Diagnosis ... #Algorithm #hematology
Pathophysiology, Signs and Symptoms of Hemolytic Anemia

#Pathophysiology #Hemolytic #Anemia #hematology #diagnosis #signs #symptoms
Pathophysiology, Signs ... and Symptoms of ... Hemolytic Anemia ... #hematology #diagnosis ... #signs #symptoms
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
- Differential Diagnosis ... deficiency • Fanconi’s anemia ... Diseases: • Systemic lupus ... Antibody-mediated hemolysis ... #Hematology
Sarcoidosis 
Non-caseating granulomas (Composed of T-helper & inflammatory cells) 
Clinical:
 • Disease fatal in 10% of
Pulmonary: Cough, hemoptysis ... Subcutaneous nodules, lupus ... #Sarcoidosis #Diagnosis ... #Symptoms #Signs
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
- Diagnosis Manifestations ... - Hemolytic anemia ... autoantibodies #signs ... #symptoms #mimickers ... #differential #rheumatology
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
1) DIAGNOSE AIHA ... • Anemia: macrocytic ... reticulocytes • Hemolysis ... #diagnosis #management ... #treatment #rheumatology
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Illness Script Signs ... and symptoms: ... Diagnosis: • Pancytopenia ... #diagnosis #management ... #treatment #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Microangiopathic hemolytic anemia ... usually IgG) (e.g. lupus ... #differential #diagnosis ... #hematology #anemia
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Features of Systemic Lupus ... ) Blood (75%): Anemia ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology