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Hyperkalemia Hypokalemia - Differential Diagnosis and Management Algorithm

Dr Pravin Patel

#Hypokalemia #Hyperkalemia #potassium #differential #diagnosis #management
Hyperkalemia Hypokalemia ... Diagnosis and Management ... Pravin Patel #Hypokalemia ... #Hyperkalemia # ... potassium #differential
Hyperkalemia Differential Diagnosis Algorithm
R/O Pseudo-hyperkalemia:
 • Possible Lab error! Alwavs Repeat Blood sample!
 • Leukocytosis, Thrombocytosis:
Hyperkalemia Differential ... Algorithm R/O Pseudo-hyperkalemia ... plasma [K+] #Hyperkalemia ... Algorithm #causes #potassium ... #high #pathophysiology
Hyperkalemia: Diagnostic algorithm
Decreased renal potassium excretion
 • Acute renal failure
 • Chronic renal failure
 • Drugs
Increased
Hyperkalemia: Diagnostic ... • Tumor lysis/hemolysis ... Normal, Renin High ... hypoplasia Aldosterone high ... • Type 1 #Hyperkalemia
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... -> Uric Acid (low ... -> Allantoin (High ... Urate Nephropathy (low ... • Hyperkalemia
Emergency management of severe hyperkalemia

#hyperkalemia #management #algorithm #nephrology #Potassium #Treatment
Emergency management ... of severe hyperkalemia ... #hyperkalemia ... #management #algorithm ... #nephrology #Potassium
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Hypokalemia - Differential ... vomiting) • Low ... MatthewHoMD #Hypokalemia ... Algorithm #nephrology #low ... #potassium
Causes of Hypokalemia - Differential Diagnosis Algorithm
Increased Loss 
 - Increased GI Loss
 - Increased Urinary
Causes of Hypokalemia ... Refeeding Syndrome #Hypokalemia ... Algorithm #causes #potassium ... #low #pathophysiology
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
patients with hypokalemia ... the basis of the potassium-to-creatinine ... EABV, High Plasma ... syndrome #hypokalemia ... #urine #potassium
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
Hypokalemia Differential ... Hypertensive: • High ... aldosteronism • High ... Gitelman's syndrome #Hypokalemia ... #potassium
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Agents to Treat Hyperkalemia ... to moderate); hypokalemia ... Hypomagnesemia; hypokalemia ... disturbances (including hypokalemia ... #Binding #Hyperkalemia