106 results
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... : • Systemic lupus ... Antibody-mediated hemolysis ... Differential #Diagnosis #Hematology
Behcet's Syndrome - Treatment
Ulcers:
 • Treatment: Topical steroids
 • Prevention: Colchicine
 • Azathioprine for refractory disease
Arthritis:
Behcet's Syndrome ... Skin manifestations ... #Syndrome #Treatment ... #management #pharmacology ... #rheumatology
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
DIAGNOSE AIHA • Anemia ... reticulocytes • Hemolysis ... FOR a cause → Systematic ... #diagnosis #management ... #treatment #rheumatology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Associated with skin ... block • Sjogren syndrome ... polymyositis overlap syndrome ... Treatment: • ... #management
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
Cholestatic liver disease ... renal failure/uremia ... Myelodisplastic syndrome ... Psychiatric Disease ... #generalized #dermatology
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Diseases Nail ... Iron deficiency anemia ... disease severe ... • Nephrotic syndrome ... #Secondary #dermatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... ) - HELLP syndrome ... Hemolytic uremic syndrome ... differential #diagnosis #hematology ... #anemia
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Sjögrens (15%) Skin ... Demyelinating syndromes ... pain (20%) Renal disease ... ) Blood (75%): Anemia ... symptoms #diagnosis #rheumatology
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Treatment
Stop offending agents:
 • List as allergies
Eosinophilia and Systemic ... Treatment Stop ... , IVIG etc • Skin ... #Treatment #Management ... #dermatology
Autoimmune Hemolytic Anemia (AIHA) Treatment
Warm AIHA:
1) Steroids - 1-2 mg/kg prednisone daily
   • Until
Autoimmune Hemolytic Anemia ... (AIHA) Treatment ... > 10, no more hemolysis ... esp if severe disease ... #management #hematology