9 results
Angioedema - Classification Diagnosis and Treatment
Types of Angioedema:
 • Acute allergic angioedema - Usually occurs with
urticaria • Hereditary ... • Mast cell-mediated ... • Bradykinin ... Mediated Chronic ... Bradykinin-mediated
Causes of Angioedema: Differential Diagnosis Framework
Mast-cell mediated:
 • IgE dependent allergic reactions: Food, Drugs, Latex, Stings
Framework Mast-cell mediated ... NSAlDs, Aspirin Bradykinin ... mediated: • ACEi ... • Hereditary C1 ... inhibitor deficiency (hereditary
Angioedema - Diagnostic Algorithm

#Diagnosis #Allergy #Angioedema #Hereditary #Acquired #C1Inhibitor #Bradykinin #Algorithm
Angioedema - Diagnostic ... Diagnosis #Allergy #Angioedema ... #Hereditary #Acquired ... #C1Inhibitor #Bradykinin
Bradykinin-mediated Angioedema
Clinical features: Submucosal oedema (face, extremity, genitalia), Laryngeal dyspnea (25% of deaths), Recurrent attacks of
Bradykinin-mediated ... Angioedema Clinical ... pain Types: • Hereditary ... vs. histamin-mediated ... #mediated #Angioedema
There are 2 Major Types of Angioedema:
 - Mast cell / histamine mediated – usually presents
Major Types of Angioedema ... cell / histamine mediated ... hypotension) - Bradykinin ... mediated – presents ... Classification #Types #Bradykinin
Stridor - Differential Diagnosis Framework:
High-pitched, variable respiratory sound

ETIOLOGIES:
Infectious:
 • Retropharyngeal abscess
 • Acute epiglottitis
 • Peritonsillar
Allergic/Immune: • Anaphylaxis ... • Hereditary ... angioedema Congenital ... malformations • Anaphylaxis ... Tracheal stenosis • Anaphylaxis
Tranexamic Acid - Indications and Pharmacology
Pharmacokinetics:
 • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
swelling in w/ hereditary ... angioedema) • ... Hypersensitivity & anaphylaxis
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
Female predominance Anaphylaxis ... lesions - Wheals/angioedema ... #rheumatology #comparison
Penicillin Allergy Pathway for Antibiotic Prescription in Patients With Penicillin Allergy
Mild Reaction - Itching, Minor rash
carbapenem Type I (lgE-Mediated ... ) HSR - Anaphylaxis ... , Angioedema, Wheezing