13 results
Tranexamic Acid - Indications and Pharmacology
Pharmacokinetics:
 • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
Indications and Pharmacology ... swelling in w/ hereditary ... angioedema) • ... Hypersensitivity & anaphylaxis ... #Indications #Pharmacology
Shock and Vasoactive Drugs 
1) Determine type and etiology of shock
 • Distributive: Sepsis, Anaphylaxis, Neurogenic
Shock and Vasoactive ... Distributive: Sepsis, Anaphylaxis ... vasoactive drug pharmacology ... Vasoactive #Drugs #pharmacology ... diagnosis #management #comparison
Stridor - Differential Diagnosis Framework:
High-pitched, variable respiratory sound

ETIOLOGIES:
Infectious:
 • Retropharyngeal abscess
 • Acute epiglottitis
 • Peritonsillar
Allergic/Immune: • Anaphylaxis ... • Hereditary ... angioedema Congenital ... malformations • Anaphylaxis ... Tracheal stenosis • Anaphylaxis
Vasopressors and Inotropes
 • Norepinephrine - Levophed - "Levo" - Generally thought of as the first
pressor added in shock ... - ACLS (1st), Anaphylaxis ... in refractory shock ... criticalcare #summary #comparison ... #table #pharmacology
Bedside Classification of Shock

Hypovolemic shock 

- Vomiting, diarrhea, overdiuresis 

- Hemorrhage (GI, peritoneal, RP) 

Distributive shock
Classification of Shock ... Hypovolemic shock ... - Septic shock ... Adrenal crisis - Anaphylaxis ... #Cardiogenic #Comparison
Manifestations of Anaphylaxis by Body System

Dermatologic/mucosal

 - Eyes: periorbital swelling/erythema, injected conjunctiva, tears

 - Oral mucosa:
Manifestations of Anaphylaxis ... - Oral mucosa: angioedema ... piloerection, angioedema ... : bradycardia, shock ... Signs #Symptoms #Anaphylaxis
Common Vasopressors and Inotropes
Norepinephrine (NE)
 - Indication: Distributive shock (1st line for septic shock), Cardiogenic shock
: Distributive shock ... ), Cardiogenic shock ... , Shock where ↑ ... Vasopressors #Inotropes #comparison ... #table #pharmacology
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
Female predominance Anaphylaxis ... lesions - Wheals/angioedema ... , Hypotension, shock ... #rheumatology #comparison
Shock - Differential Diagnosis Framework
MAP = CO x SVR
Hypovolemic (↓ Intravascular volume):
 • Hemorrhage, dehydration due
Shock - Differential ... Sepsis. neurogenic, anaphylaxis ... uw_IMresidency #Shock ... Diagnosis #table #comparison
Vasopressors and Inotropes - Pharmacology Summary
Vasopressors
Phenylephrine (alpha-1)
 • Increases BP, SVR
 • Risk of reflex bradycardia
and Inotropes - Pharmacology ... first agent in shock ... • 1st agent in anaphylaxis ... line in septic shock ... Vasopressors #Inotropes #Pharmacology