40 results
Tranexamic Acid - Indications and Pharmacology
Pharmacokinetics:
 • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
swelling in w/ hereditary ... angioedema) • ... Hypersensitivity & anaphylaxis ... #Pharmacology #hematology
Facial Swelling from Hereditary Angioedema on Physical Examination

19 year old Hereditary Angioedema (HAE) patient from Turkey.
Swelling from Hereditary ... Angioedema on Physical ... 19 year old Hereditary ... Angioedema (HAE ... #Angioedema #clinical
Stridor - Differential Diagnosis Framework:
High-pitched, variable respiratory sound

ETIOLOGIES:
Infectious:
 • Retropharyngeal abscess
 • Acute epiglottitis
 • Peritonsillar
Allergic/Immune: • Anaphylaxis ... • Hereditary ... angioedema Congenital ... malformations • Anaphylaxis ... Tracheal stenosis • Anaphylaxis
Angioedema - Classification Diagnosis and Treatment
Types of Angioedema:
 • Acute allergic angioedema - Usually occurs with
Angioedema - Classification ... Treatment Types of Angioedema ... Acute allergic angioedema ... urticaria • Hereditary ... angioedema - Rare
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
deposition disease, hereditary ... angioedema A - ... #differential #hematology
Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
Anaphylaxis: Signs ... and Symptoms Anaphylaxis ... dyspnea, hypoxia • Angioedema ... Urticaria • Angioedema ... #Anaphylaxis
Clinical manifestations of anaphylaxis. 
Neurological (<15%): Dizziness, syncope, seizures, Confusion, impending doom. headache
Angioedema: Lips, tongue, orbit,
manifestations of anaphylaxis ... doom. headache Angioedema ... incontinence #anaphylaxis
Manifestations of Anaphylaxis by Body System

Dermatologic/mucosal

 - Eyes: periorbital swelling/erythema, injected conjunctiva, tears

 - Oral mucosa:
Manifestations of Anaphylaxis ... - Oral mucosa: angioedema ... piloerection, angioedema ... Signs #Symptoms #Anaphylaxis
Effect of Selected Diseases on Complement Levels - C3, C4
 • SLE C3 ↓ C4 ↓↓
C3 ↓ C4 ↓↓ • Hereditary ... angiooedema C3
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Defects • Hereditary ... spherocytosis • Hereditary ... Algorithm #Causes #Hematology