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diagnosis differential algorithm causes hematology management clinical pulmonary symptoms pathophysiology signs nephrology workup hemolytic cardiology neurology treatment deficiency pharmacology classification
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... Diagnosis Algorithm Hereditary ... → Sickle Cell anemia ... → Hereditary spherocytosis ... anemia (TTP, HUS
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis ... and RES-mediated hemolysis ... Defects • Hereditary ... spherocytosis • Hereditary ... anemia •
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Intravascular Hemolysis ... anemia): ... defects (e.g. hereditary ... diagnosis #hematology #anemia
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... membrane disorder (hereditary ... spherocytosis, hereditary ... ARUPConsult @ARUPLabs #Hemolytic ... #Anemia #Differential
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Iron-deficiency anemia ... Spherocytes - Hereditary ... spherocytosis, Hemolytic ... Elliptocytes - Hereditary ... Schistocytes - Hemolytic
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Microangiopathic Hemolytic ... drugs Elliptocyte: Hereditary ... Spherocyte: Hereditary ... : Hereditary stomatocytosis ... Cold autoimmune hemolytic
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Diagnosis for Hemolytic ... Anemia Intrinsic ... Hereditary spherocytosis ... udaygulati #Hemolytic ... #Anemia #Differential
Spherocytes - The arrow points to one of many spherocytes in this photo. The cells have
formation include hereditary ... spherocytosis and hemolytic ... anemias.
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
production (eg, hemolytic ... anemias, hemolytic ... bilirubin) • Hereditary
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Algorithm Signs of anemia ... Anemias (AIHAs) ... Anemias (AHAs) ... #Anemias #Differential
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