29 results
There are 2 Major Types of Angioedema:
 - Mast cell / histamine mediated – usually presents
- Mast cell / histamine ... hypotension) - Bradykinin ... Classification #Types #Bradykinin
Bradykinin-mediated Angioedema
Clinical features: Submucosal oedema (face, extremity, genitalia), Laryngeal dyspnea (25% of deaths), Recurrent attacks of
Bradykinin-mediated ... female, ACEI) Bradykinin ... vs. histamin-mediated ... Clara Vigneron #Bradykinin
Drug-Induced Edema
Drug-induced edema is caused by many drugs & can coincide with or worsen pre-existing peripheral
which include: - Bradykinin ... permeability) - Histamine
Pressor area
1a
Neuronal
Sympathetic
tonus t
Vessel stretch
Myogenic reaction
2a local
Port
Endothelin-1 1 (ETA)
PGF2a,
thromboxane
Constriction
ADH (V1),
epinephrine (a1), angiotensin lI
За
Hormonal
1b
Neuronal
Sympathetic tonus
Dilation
Parasympathetic system (salivary glands,
Bradykinin, 4 kallidin ... Acetylcholine (M), АТР, #histamine
Sleep
Regulation of sleep is critical for life! Ever wonder why you can’t fall asleep while hungry
hungry or why anti-histamines ... #Sleep #anti-histamine
Effects of H1 Antihistamines at Histamine, Adrenergic, Cholinergic, and Serotonin-Binding Receptors
Cholinergic - Incr Dry mouth, Incr
Antihistamines at Histamine ... Incr Appetite Histamine
Angioedema - Classification Diagnosis and Treatment
Types of Angioedema:
 • Acute allergic angioedema - Usually occurs with
Bradykinin ... angioedema • Bradykinin-mediated
Intern Pocket Cards - Inpatient Anti-Emetics Guide
Serotonin antagonists:
 • Ondansetron (Zofran), Granisetron (Kytril, Sancuso) - Headache,
EPS, dry mouth Histamine ... retention DA/Histamine
Second Generation Antipsychotics: Mechanisms and Side Effects
(Atypical Anti-Psychotics) - Examples: Clozapine, Olanzapine, Quetiapine, Risperidone, Zotepine, Paliperidone,
muscle dilation • Histamine ... Antagonism - Block Histamine
Erythroderma - Diagnostic Algorithm. Pathophysiology: 1) Extensive cutaneous capillary dilation, results in widespread exfoliation of the
Eosinophils 3) Basophils/Histamine