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diagnosis anemia algorithm classification dermatology extravascular hemolysis intravascular management rheumatology spleen splenomegaly alopecia calculation china enlarged framework hair hairloss hepatitis
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... drug induced • Infections ... Bartonella, Babesia ... classification #hematology
Causes of Hemolytic Anemia - Differential Diagnosis Inherited • Membrane • Internal - Hemoglobin
Causes of Hemolytic ... Anemia - Differential ... Internal - Infectious ... #Diagnosis #Causes ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... spherocytosis) • Infections ... Extravascular #Causes ... #differential # ... diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... - Differential ... circulation - Infections ... Extravascular #Differential ... #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... inclusions - If infection ... (oroya fever), babesia ... #Anemia #Differential ... Algorithm #workup #hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
- Differential ... Diagnosis Algorithm Infectious ... Serum Sickness Hemolytic ... Spleen #Enlarged #Differential ... #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
B12, Folate • Hormone ... (e.g. cancer, infection ... Microangiopathic hemolytic ... Production #Index #hematology ... #anemia #differential
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... - Differential ... Parasitic: Malaria, babesia ... infiltration: malignancy, infection ... Diagnosis #Framework #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... - Differential ... Thrombocytosis): • Acute infection ... iron deficiency, hemolysis ... #hematology #secondary
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... DIC/TTP/HUS - Hemolytic ... SLE) - Viral infections ... APLS • Acute Infectious ... Vasculopathy #Purpura #Differential
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