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diagnosis differential management causes hematology cardiology algorithm signs dermatology neurology rash rheumatology sepsis symptoms treatment chronic criteria hemophagocytic hlh infectiousdiseases
SEPSIS AND SEPTIC SHOCK DEFINITION AND PATHOPHYSIOLOGY • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
Life-threatening organ dysfunction ... cellular/metabolic dysfunction ... Infection + Organ dysfunction ... /hypofunction. ... • Symptoms: Fever
Fever and Rash - Differential Diagnosis Framework • Viral: Measles, Infectious Mono (EBV, CMV), Acute HIV,
Fever and Rash - ... diseases, Toxic shock ... syndrome, TB cutis ... , DRESS, Sweet syndrome ... Medicine @SCVMCMed #Fever
Systemic Inflammatory Response Syndrome (SIRS) Criteria - Definitions of Sepsis, Severe Sepsis and Septic Shock Systemic Inflammatory
Inflammatory Response Syndrome ... Sepsis and Septic Shock ... Inflammatory Response Syndrome ... drop > 40 (Organ dysfunction ... hypoperfusion) Septic Shock
Erythematous Rashes - THE ALGORITHMIC APPROACH Characterized by diffuse redness of the skin due to capillary congestion, erythematous
or absence of fever ... staphylococcal scalded skin syndrome ... If fever is present ... , and toxic shock ... syndrome (TSS)
Clinical Manifestations of Serotonin Syndrome • Ophthalmologic: Mydriasis, Ocular clonus (slow horizontal movements) • Gastrointestinal: Diarrhea,
Manifestations of Serotonin Syndrome ... : Tachycardia, Fever ... , Late stages (shock ... ucsdim #Serotonin #Syndrome
Bradycardia - Differential Diagnosis Framework BRADI Mnemonic • BRASH/Hyperkalemia • Reduced oxygen/Glucose/Temp • ACS • Drugs •
Infections BRASH Syndrome ... blocking agent • Shock ... • Tachy-Brady syndrome ... Acute rheumatic fever ... • Yellow fever
Neurological Manifestations of Tuberculosis Spinal Arachnoiditis & Polyradiculopathy: • Subacute onset of limb weakness, bladder/bowel dysfunction, muscle
bladder/bowel dysfunction ... Reconstitution Inflammatory Syndrome ... neurologic symptoms, fever ... ) • Headache, fever ... Meningitis: • Fever
Causes of Acute Onset Fever - Differential Diagnosis Algorithm Viral: • Rhinovirus • Influenza Virus • Parainfluenza
of Acute Onset Fever ... Bacteremia Septic Shock ... Neuroleptic malignant syndrome ... disease • Drug fever ... #Fever #Acute
Lactic Acidosis - Differential Diagnosis Framework Type A: Impaired O2 Delivery (DO2) • Decreased O2 Delivery: Hypotension
Cardiogenic & Septic Shock ... Ischemia, Compartment Syndrome ... Pain / Exercise, Fever ... Microcirculatory dysfunction ... in Short Bowel Syndrome
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
Causes of Fever ... Lemierre's syndrome ... Brucellosis, Q fever ... , Factitious fever ... , Hypothalamic dysfunction
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