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diagnosis autoantibodies differential table ana antinuclear diseases erythematosus management systemic algorithm anca antibody antineutrophil arterial classification embolism glomerulonephritis progressive rapidly
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... others (RNP, aPL antibodies ... Polymerase Ill • ANCA Vasculitis ... Autoantibodies #Rheumatology ... #diagnosis #associations
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
their Disease Associations ... disease c-ANCA - Vasculitis ... Autoantibodies #Associations ... diagnosis #table #rheumatology ... #antibodies
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... Post-strep GN, Lupus ... Purpura Anti-GBM antibodies ... Glomerulonephritis #Vasculitis ... diagnosis #algorithm #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... Anti-dsDNA 60-80% Association ... SLE-SSc-AlM overlap syndromes ... Negative association ... erythematosus #diagnosis #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... ) • Systemic lupus ... cases • Sjögren syndrome ... ANCA-Associated Vasculitis ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... 1, SCL-70, RNP antibodies ... anticardiolipin antibodies ... Erythematosus #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... • Cogan Syndrome ... such as systemic lupus ... C-ANCA) pattern: antibodies ... differential #diagnosis #rheumatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
• Nephrotic Syndrome ... Antiphospholipid antibodies ... 19 - PNH - Vasculitis ... Venous #Arterial #pathophysiology ... #hematology #differential
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
) • Cutaneous vasculitis ... Nephrogenic DI Hematologic ... : 2% Systemic Vasculitis ... lubricants • Pharmacologic ... #Rheumatology #
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
TAFRO TAFRO syndrome ... including systemic lupus ... ANCA-associated vasculitis ... cell lymphoma Pathophysiology ... diagnosis #management #rheumatology
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