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differential rheumatology lupus cardiology table erythematosus management comparison endocarditis hematology nephrology syndrome types vasculitis allergy hypersensitivity msk obgyn obstetrics reactions
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... glomerulonephritis (>90%) S - Systemic ... @AnnKumfer #Hypocomplementemia ... #Low #Complement ... CHAMPS #Mnemonic #diagnosis
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Constitutional domain: Fever ... anticoagulant • Complement ... #Criteria #SLE ... Erythematosus #diagnosis
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... Positive in 60-80% of cases ... 80% - Low complement ... #lupus #Systemic
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... Vasculitis: • Fevers ... against MPO • Complement ... vasculitis, and SLE ... #rheumatology #classification
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis Algorithm Neoplasm: • NHL • Hodgkin's lymphoma • Leukemia • Solid
Causes of Fever ... - Differential Diagnosis ... Algorithm Neoplasm ... Autoimmune: • SLE ... #Algorithm #causes
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
90% - Low complement ... Discontinuation of causal ... months to years) Systemic ... 80% - Low complement ... #rheumatology #diagnosis
Systolic Murmurs - Differential Diagnosis Algorithm Benign / Flow / Hyperdynamic: • Pregnancy • Fever • Anemia Supravalvular
Systolic Murmurs ... - Differential Diagnosis ... Algorithm Benign ... Carcinoid #Systolic ... #Algorithm #causes
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
- Local and systemic ... , seasonal hay fever ... Complement activation ... Hypersensitivity #Types #Classification ... Pathophysiology #Allergy #Diagnosis
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
- Differential Diagnosis ... Algorithm Persistent ... • Exercise • Fever ... (MPA) • SLE ... #Algorithm #Causes
Primary and Secondary Causes of Mitral Regurgitation Primary (organic) chronic mitral regurgitation: • Leaflet: Rheumatic fever, Infective
and Secondary Causes ... cushion defects), Systemic ... inflammation (SLE ... #differential #diagnosis ... #cardiology #causes
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