21 results
diagnosis differential hematology anemia causes glomerular management nephrology nephrotic rheumatology vasculitis workup autoimmune blood cold disease primarycare product reactions syndrome
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
fragmentation hemolysis ... toxin-mediated hemolytic-uremic ... ) - Complement-mediated ... • Mechanical hemolysis ... macroangiopathic hemolytic
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic ... Urticarial #Vasculitis #HUV
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Cold Autoimmune Hemolytic ... Warm Autoimmune Hemolytic ... Cold Autoimmune Hemolytic ... Mostly transient hemolysis ... Cold #Autoimmune #Hemolytic
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis ... and RES-mediated hemolysis ... Intravascular - Hemolysis ... immune-complex hemolytic ... malformations #Hemolysis
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... A - Atypical HUS ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... Immune mediated hemolysis ... Microangiopathic hemolytic ... anemia (TTP, HUS ... UnremarkableLab #Hemolytic
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... DIC, TTP, HELLP, HUS ... elliptocytosis, autoimmune hemolysis ... ARUPConsult @ARUPLabs #Hemolytic ... workup #hematology #testing
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Diagnosis: • hemolytic ... Positive Coombs testing ... • Compensated hemolysis ... intravascular hemolysis ... agglutinin #disease #hemolytic
Autoimmune Hemolytic Anemia (AIHA) WARM AHA - Primary - Idiopathics - Secondary Infectious • Viral- HIV, EBV, HCV, HEV •
Autoimmune Hemolytic ... Infectious • Viral- HIV ... , EBV, HCV, HEV ... #Autoimmune #Hemolytic ... #Differential #Algorithm
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. TTP/HUS indicates thrombotic
Algorithm for workup ... TTP/HUS indicates ... thrombocytopenic purpura/hemolytic ... #Differential #Algorithm
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