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diagnosis rheumatology differential vasculitis lupus criteria systemic ahus arthritis atypical c3 c4 champs cryoglobulinemia cryoglobulins disease eularacr hematology hemolytic huv
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... A - Atypical HUS ... Systemic Lupus Erythematosus ... @AnnKumfer #Hypocomplementemia ... #Low #Complement
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... Complex Formation - Complement ... TerrierBen #Hypocomplementemic ... Urticarial #Vasculitis #HUV
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Selected Diseases on Complement ... Levels - C3, C4 ... • SLE C3 ↓ C4 ... C3 ↓ C4 → • HUS ... #Levels #C3 #C4
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
anti-GBM) 10%: - Low Complement ... Levels: SLE, Cryoglobulinemic ... Levels: Scleroderma ... hypertension - MAHA: HUS ... , atypical HUS,
Atypical HUS - Hemolytic Uremic Syndrome Unlike typical HUS, which is shigatoxin mediated, aHUS is not typically
Unlike typical HUS ... autoimmune like SLE ... It is complement ... need the ADAMTS13 level ... with Eculizumab (complement
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often involved • Hypocomplementemic ... Urticaria and hypocomplementemia ... against MPO • Complement ... (Low levels mixed ... vasculitis, and SLE
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... Systemic Lupus Erythematosus ... CRITERIA - ANA level ... anticoagulant - Low complement ... #Rheumatology #SLE
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... Skin Disease Classification ... RNP antibodies, Complement ... levels (C3 and
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Systemic Lupus Erythematosus ... anticoagulant • Complement ... #EULARACR #Classification ... #Criteria #SLE
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Systemic lupus erythematosus ... (SLE) - Antinuclear ... 30% and 60% of SLE ... antibody testing has ... have ANAs; thus
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