7224 results
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
IgG4-Related Disease ... Clinical history ... node), high serum IgG4 ... rheumatoid factor), ± hypocomplementemia ... with increased IgG4
Diagnosis and Management of Hypocomplementemic Urticarial Vasculitis (HUV)

Diagnosis of HUV
1) Chronic urticaria 
2) Leukocytoclastic vasculitis 
3)
Management of Hypocomplementemic ... vasculitis 3) Hypocomplementemia ... TerrierBen #Hypocomplementemic
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology of Hypocomplementemic ... TerrierBen #Hypocomplementemic
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... @AnnKumfer #Hypocomplementemia
IgG4-associated conditions

Diagnosis of IgG4 disease is depending on BIOPSY. While IgG4 levels can be informative (and
IgG4-associated ... Diagnosis of IgG4 ... While IgG4 levels ... inflammation of IgG4 ... #IgG4 #conditions
Manifestations of IgG4-related disease by organ system.
 The most common primary disease features are indicated in
Manifestations of IgG4 ... #IgG4 #Manifestations
Expected DAT Results in Autoimmune Hemolysis
DAT Negative Hemolysis
 • DAT Poly ( - ), IgG (
DAT Poly ( - ), IgG ... DAT Poly ( + ), IgG ... DAT Poly ( + ), IgG ... Poly ( +/- ), IgG ... DAT Poly ( + ), IgG
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
AIHA: - 70%; IgG ... mediated - DAT: IgG ... mediated - DAT: IgG
Aortitis - Diagnosis and Workup
Clinical History:
 - Fever, weight loss, deterioration of general health
 - Aortic
Diagnosis and Workup Clinical ... Behqet, Cogan, IgG4
You’ll notice there is an IgM and an IgG core antibody. The presence of IgM anti-HBc
an IgM and an IgG ... The presence of IgG ... infected with HBV, IgG ... commonly run in the clinical ... means IgM and IgG