Hyponatremia Differential endocrinology comparison hypercalcemia diagnosis secondary calcium primary hyperparathyroidism indications highcalcium pth adrenal

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Hypercalcemia - Differential Diagnosis Algorithm
Primary Hyperparathyroidism
• Adenoma
• Hyperplasia
• MEN 1 and 2A
Tertiary Hyperparathyroidism

Differential Diagnosis ... Algorithm Primary ... long-standing secondary ... #Endocrinology ... #HighCalcium

Hyperparathyroidism - Primary vs Secondary vs Tertiary
Lab Comparison:
• Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,

- Primary vs Secondary ... : ↑→PTH, ↑Calcium ... : ↑PTH, ↓→Calcium ... : ↑↑PTH, ↑Calcium ... #diagnosis #endocrinology

Causes of Hypercalcemia
Hypercalcemia due to increased bone Ca2+ resorption:
• Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,

resorption: • Primary ... hyperparathyroidism ... #Causes #differential ... #diagnosis #calcium ... #high #endocrinology

Hypocalcemia - Differential Diagnosis Algorithm - Low and High Phosphate
LOW PHOSPHATE
- Low/NormaI PTH

Hypocalcemia - Differential ... Diagnosis Algorithm ... ) • Calcium ... • Secondary ... #Phosphate #endocrinology

Hypercalcemia - Differential Diagnosis Algorithm
Elevated PTH (High or normal):
• Primary Hyperparathyroidism
• Familial Hypocalciuric Hypercalcemia
Low

Differential Diagnosis ... or normal): • Primary ... Hyperparathyroidism ... Bony Mets - Calcium ... #causes #endocrinology

Adrenal Insufficiency Differential Diagnosis Algorithm
Clinical suspicion: Weakness, fatigue, nausea, musculoskeletal pain, dizziness, volume depletion, abdominal pain,

Differential Diagnosis ... , hypotension, hyponatremia ... , hyperkalemia, ... baseline ACTH - Primary ... #endocrinology

Causes of Hypercalcemia
Parathyroid gland structure-related
• Primary hyperparathyroidism
• Parathyroid adenoma
• Parathyroid hyperplasia
• Parathyroid

Hyperuricemia - Differential Diagnosis Algorithm
Primary - Over-production
• Increased turnover of nucleotides
Primary

Hyperuricemia - Differential ... Diagnosis Algorithm ... Endocrine • Hyperparathyroidism ... Sarcoidosis • Hypercalcemia ... #endocrinology

Causes of Hypocalcemia by Clinical Cause

Acute illness: pancreatitis, tumor lysis, severe illness - Secondary hyperparathyroidism from

hyperparathyroidism ... low circulating calcium ... gland removal Renal ... #Causes #Differential ... #Diagnosis #Endocrinology

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Causes of Hypocalcemia - Differential Diagnosis
Decreased calcium absorption
• Vitamin D deficiency
-

Causes of Hypocalcemia ... - Differential ... Diagnosis Decreased ... resorption • Hypoparathyroidism ... #endocrinology

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