32 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... to Kidney: Anti-GBM ... With associated pulmonary ... Glomerulonephritis #Vasculitis #differential ... diagnosis #algorithm #rheumatology
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Still's Disease Clinical ... fraction < 20% Differential ... hepatitis • Pulmonary ... Disease #diagnosis #management ... #treatment #rheumatology
Major Clinical Trials and Evidence Summary for Transfusion Thresholds in Critical Care

TRICC - NEJM 1999 -
Major Clinical Trials ... - NEJM 1999 - ICU ... unnecessary and cause ... /vmoitra) #EBM ... Transfusion #Thresholds #Hematology
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
coagulopathy) • CBC w differential ... antibody, Anti-GBM ... Goodpasture's cause ... Renal #Syndromes #differential ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Drugs, Unknown cause ... of emergency, ICU ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Clinical Classification of Pulmonary Hypertension

1. Pulmonary arterial hypertension from pulmonary vasculopathy
Idiopathic pulmonary arterial hypertension
Heritable gene mutations
Clinical Classification ... Pulmonary arterial ... receptor type II-like ... Classification #Diagnosis #Differential ... #Causes
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Creatine Kinase - Causes ... (COVID19, CMV/EBV ... immobility • Critical ... Illness Myopathy (ICU ... #Elevated #CK #differential
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
VII, X, V and II ... organ damage Clinical ... Treat primary cause ... #treatment #management ... #hematology
Lung Abscess - Diagnosis and Management Summary

Lung Abscess Etiology:
 • Necrosis of lung parenchyma by a
Lung Abscess - Clinical ... Lung Abscess Differential ... Lung #Abscess #pulmonary ... #differential # ... causes #management
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Imaging: CXR- pulmonary ... initiation • Differential ... organ dysfuxtion, ICU ... APML #diagnosis #management ... #hematology #oncology