23 results
Treatment of Thrombotic Thrombocytopenic Purpura (TTP)
Diagnosis of TTP:
 • Rare and severe, ADAMTS13 deficiency
 • Autoimmune
Treatment of Thrombotic ... HUS) Treatment ... admission to the ICU ... #rheumatology # ... hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... 5 or elevated Cr ... - pulmonary opacities ... organ dysfuxtion, ICU ... diagnosis #management #hematology
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
bleeding disorder Clinical ... • Normal PT/INR ... factor VIII) Treatment ... Disease #Diagnosis #Hematology
Major Clinical Trials and Evidence Summary for Transfusion Thresholds in Critical Care

TRICC - NEJM 1999 -
Major Clinical Trials ... Thresholds in Critical ... - NEJM 1999 - ICU ... Transfusion #Thresholds #Hematology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
Risk factors: Critical ... : 33% • Treatment ... fluid balance, and CXR ... with pulmonary ... Transfusion #Reactions #hematology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
, dyspnea, +/- CXR ... organ damage • Treatment ... acid, Elevated Cr ... Low calcium • Treatment ... diagnosis #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... Unknown cause Treatment ... of emergency, ICU ... #summary #rheumatology
Giant Cell Arteritis (GCA) - Vasculitis Management Algorithm - ACR/VF 2021 Guidelines
 • Visual Symptoms/Loss or
Management Algorithm - ACR ... Symptoms/Loss or Critical ... Symptoms/Loss or Critical ... Vasculitis #Management #Treatment ... Guidelines #algorithm #rheumatology
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Still's Disease Clinical ... hepatitis • Pulmonary ... diagnosis #management #treatment ... #rheumatology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
> MICU, ♀, ↑Age ... Diagnosis: • Clinical ... non-heparin A/C if clinical ... Diagnosis #Management #Treatment ... #Hematology #HemeOnc