48 results
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... • Immunologic Workup ... Positive in 60-80% of cases ... Evolution: Chronic disease ... #Summary #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... disease, decrease ... disease), HBsAg ... a primary hematologic ... #Workup #hematology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... Discontinuation of causal ... • Immunologic Workup ... Evolution: Chronic disease ... comparison #table #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
highly inflammatory disease ... • Systemic lupus ... SJIA], systemic lupus ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Hydroxychloroquine Serum Measurement in SLE
 • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
malabsorption) if ... • Special cases ... Measurement #SLE #rheumatology ... pharmacology #levels #lupus ... #management
Top 10 situations when to think about lupus
1) Inflammatory joint pain (especially in the wrists and
to think about lupus ... ANA) [especially if ... 9) Unexplained fever ... including in children (pediatric ... erythematosus #rheumatology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Causes of Anemia ... • Pancreatic Disease ... Disease #Macrocytic ... Diagnosis #Algorithm #Causes ... #Hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic Lupus ... Cerebrovascular Disease ... autoantibodies that will cause ... CNS #neurology #rheumatology ... cerebritis #diagnosis #management
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
4th decades of life ... Causes and clinical ... symptoms - Headache, fever ... , fatigue, Nausea ... Urticaria #diagnosis #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... Post-strep GN, Lupus ... involvement: Anti-GBM Disease ... mediated (Negative IF ... diagnosis #algorithm #rheumatology