32 results
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... glucocorticoid treatment ... organ-specific signs ... or symptoms (eg ... #Differential #diagnosis
Gaucher Disease 

Pathophsiology
 • Lysosomal storage disorder
 • Deficiency of ß-glucocerebrosidase
• Accumulation of glucosylceramide in macrophages
Diagnosis
Gaucher Disease Pathophsiology ... Lysosomal storage disorder ... in macrophages Diagnosis ... in GBA1 gene Clinical ... #Signs #Symptoms
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Lymphoproliferative Disorders ... - Differential Diagnosis ... pattern of spread, B symptoms ... Classification #pathophysiology ... #Hematology #Diagnosis
Bipolar Disorder: Pathogenesis and Clinical Findings
 • Disruption of emotional homeostasis
 • Oscillation between mood states
Pathogenesis and Clinical ... mood - Primary treatment ... MoodDisorders #Diagnosis ... #Pathophysiology ... #Signs #Symptoms
Major Depressive Disorder (MDD): Pathogenesis and Clinical Findings

Symptoms (included in DSM 5 criteria) - Present during
Major Depressive Disorder ... Pathogenesis and Clinical ... MoodDisorders #Diagnosis ... #Pathophysiology ... #Signs #Symptoms
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... WBC >100k, + lab signs ... Lysis Syndrome: • Pathophysiology ... Syndrome #TLS #diagnosis ... #management #hematology
Alcohol Use Disorder: Pathogenesis and Clinical Findings

 • Tolerance (reduced sensitivity to effects of EtOH)
 •
Alcohol Use Disorder ... Pathogenesis and Clinical ... AlcoholUseDisorder #EtOH #Pathophysiology ... #Diagnosis #Signs ... #Symptoms #Psychiatry
Multiple Sclerosis - Summary

Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
impairment, Mood disorder ... Signs and symptoms ... patients with clinically ... stimulation Clinical ... Multiple Sclerosis Treatment
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
leukemia in adults • Disorder ... minimal tumor burden Diagnosis ... immunophenotype Clinical ... Leukemia #oncology #hematology ... #hemeonc #diagnosis
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
Risk factors: Critical ... ARDS to explain symptoms ... : 33% • Treatment ... : No • Treatment ... #diagnosis #comparison