221 results
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
• Direct renin inhibitor ... Renin release inhibition ... of aldosterone inhibition ... pathophysiology #pharmacology
Allopurinol and its active metabolite inhibit xanthine oxidase, the enzyme that converts hypoxanthine to xanthine and
Inhibition of this ... #pharmacology #overview ... druginformation #nephrology
HIV Antiretroviral Pharmacokinetic Boosters - Ritonavir & Cobicistat 

Ritonavir & Cobicistat are 2 pharmacokinetic boosters used
actually a protease inhibitor ... and a 3A4 inhibitor ... is just a 3A4 inhibitor ... because of the CYP inhibition ... HIV #Boosters #Pharmacology
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
carbonic anhydrase inhibitor ... nephron #diuretics #pharmacology ... #nephrology #medications
Antiplatelet Medications - Summary Table

Aspirin - Inhibits cyclooxygenase, preventing formation of thromboxane A2
 • Acute coronary
combination with P2Y12 inhibitor ... Dipyridamole - PDE5 inhibition ... (and PDE3 inhibition ... Cilostazol - PDE3 inhibition ... Summary #Table #Pharmacology
Anticoagulant specific factor inhibition. 

#anticoagulation #clotting #INR #heparin #LMWH #NOAC #warfarin #coumadin #rivaroxaban  #Xarelto #apixaban
specific factor inhibition ... Pradaxa #management #pharmacology
Amiodarone Toxicity and Monitoring

Tremor Ataxia 
Ocular neuritis 
Corneal Microdeposits 
Bradycardia 
Pulmonary fibrosis 
Hepatotoxicity 
Blue-gray skin
Tremor Ataxia Ocular ... Substrate CYP3A4 - Inhibitor ... Diagnosis #Management #Pharmacology
Immune Reactions and Immunosuppressant Drugs

Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2
Muromonab-CD3 - Monoclonal antibody
Calcineurin
Glucocorticoids - Inhibition ... Calcineurin inhibitors - Inhibition ... Immunosuppressant #Drugs #Pharmacology
Proton Pump Inhibitor (PPI) - Adverse Effects and Prescribing Tips

#Management #Pharmacology #PPI #Adverse #SideEffects #Prescribing #ProtonPumpInhibitor
Proton Pump Inhibitor ... #Management #Pharmacology
Important Cardiac Transplant Medications and Side Effects
 • Cyclosporine (Sandimmune, generic) - Calcineurin inhibitor, decreasing T
- Calcineurin inhibitor ... - Calcineurin inhibitor ... , inhibiting T lymphocyte ... Medications #drugs #pharmacology