32 results
Warm vs Cold Autoimmune Hemolytic Anemia
Warm Autoimmune Hemolytic Anemia:
 • Mechanism: IgG and Complement-mediated
 • Etiology:
Warm vs Cold Autoimmune ... Immunosuppression, Splenectomy Cold ... BostonChiefs #Warm #Cold ... #hematology #diagnosis ... #comparison
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
Involving the Skin ... related vasculitis, infections ... Vasculitis Skin ... #Vasculitis #skin ... #dermatology #rheumatology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
presentation) • Cutaneous ... • Symptoms of anemia ... • hemolytic anemia ... disease #hemolytic #anemia ... #hematology #diagnosis
Urticaria (hives): Skin reaction that occurs in response to cold, food allergies, meds, environmental exposures, stings,
infections
Urticaria (hives): Skin ... in response to cold ... exposures, stings, infections ... Images #Clinical #Photo ... #Dermatology #SkinRash
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... Autoimmune (AIHA)"Cold ... (e.g. primary cold ... differential #diagnosis #hematology ... #anemia
Staphylococcal Scalded Skin Syndrome (SSSS)

A 5-year-old girl presents to the ED with a rash that started
Staphylococcal Scalded Skin ... SSSS) A 5-year-old ... upper respiratory infection ... SSSS #Clinical #Photo ... Peds #Pediatrics #Dermatology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Warm AIHA • Cold ... circulation - Infections ... Complement-Mediated • Cold ... immune-complex hemolytic anemia ... Algorithm #Causes #Hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
for Hemolytic Anemia ... • AIHA: warm, cold ... drug induced • Infections ... #Hemolytic #Anemia ... classification #hematology
Autoimmune Hemolytic Anemia (AIHA) Treatment
Warm AIHA:
1) Steroids - 1-2 mg/kg prednisone daily
   • Until
Autoimmune Hemolytic Anemia ... azathioprine Cold ... Polyclonal: - Infection ... Autoimmune #Hemolytic #Anemia ... Treatment #management #hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Autoimmune: Warm AIHA, Cold ... Internal (RBC) - Infections ... Defects: Sickle cell anemia ... Differential #Diagnosis #hematology