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management differential neurology rheumatology syndrome treatment bleeding bruising hemophagocytic hlh lymphohistiocytosis summary abnormal adjusted age algorithm aptt arterial barre cascade
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... - Differential Diagnosis ... Proteins - Acquired ... #Algorithm #Causes ... #Hematology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Summary of Coagulation ... of Factor IX Acquired ... Acute DIC - Septic shock ... table #comparison #diagnosis ... #hematology #deficiency
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... dysfunction (16%) • Shock ... Treat primary cause ... #diagnosis #causes ... treatment #management #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Acquired deficiency ... Pre-analytical cause ... #diagnosis #differential ... #hematology #coagulation
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
THROMBOSIS • Acquired ... intravascular coagulation ... and other causes ... Venous #Arterial #pathophysiology ... #hematology #differential
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Differential Diagnosis ... inhibitor of a coagulation ... discern these causes ... #Differential #Diagnosis ... #Hematology
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
) -> Increased coagulation ... • Hematologic ... retinal edema caused ... Occlusion #CRAO #pathophysiology ... ophthalmology #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Auto-amplification loop Diagnosis ... Purtilo (XLP) Acquired ... Drugs, Unknown cause ... treatment #summary #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... autoantibodies that will cause ... permeability Diagnosis ... #rheumatology # ... cerebritis #diagnosis
D-dimer Plasma D-dimer is a product of clot breakdown, released upon degradation of polymerized, crosslinked fibrin. Elevated
indicate that coagulation ... age, which can cause ... Ddimer #dimer #pathophysiology ... #hematology #differential ... #diagnosis #age
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