82 results
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
of Factor IX Acquired ... Acute DIC - Septic shock ... Deficiencies #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
• +ANA can be seen ... , Drug-induced Lupus ... , Drug-Induced Lupus ... #patterns #rheumatology ... #diagnosis #differential
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... and Management ... Workup: - ANA ... Evolution: Chronic disease ... #rheumatology
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Lupus (SLE): ... ANA (anti-nuclear ... Citrullinated Peptide (CCP ... #diagnosis #associations ... #table
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Acquired von Willebrand ... Syndrome - Diagnosis ... and Management ... thrombocythemia), Autoimmune disease ... #hematology #differential
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Association with disease ... Can also be measured ... erythematosus #diagnosis ... #rheumatology # ... table #ANA
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Malignancy (e.g. hematologic ... vein thrombosis Hematologic ... Erythematosus #Diagnosis ... #Rheumatology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... Antinuclear (ANA ... #SLE #Summary #diagnosis ... #rheumatology # ... management
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Workup: - ANA ... Evolution: Chronic disease ... sle #comparison #table ... #rheumatology # ... diagnosis #management
Shock and Vasoactive Drugs 
1) Determine type and etiology of shock
 • Distributive: Sepsis, Anaphylaxis, Neurogenic
Shock and Vasoactive ... Failure, Valvular Disease ... #inopressors #diagnosis ... #management #comparison ... #table