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management diagnosis pharmacology cap infectiousdiseases pneumonia sepsis sirs acute algorithm antimicrobials bactrim cdi cdiff clostridioides clostridium cns coverage criteria criticalcare
Antibiotic treatment durations for first line antibiotics recommended by Public Health England (PHE) guidance • Acute
Antibiotic treatment ... acquired pneumonia ... CRB65=0 7 days • Community ... acquired pneumonia ... and CRB65=1 7-10
Antibiotics for severe community-onset pneumonia Atypical coverage always - Usually azithromycin 500 mg daily - Doxycycline
severe community-onset ... piperacillin-tazobactam Septic Shock ... Hospitalization for > 1 ... - Linezolid 1 ... #Acquired #Pneumonia
Algorithm for the Evaluation of Acute Diarrhea (< 7 days) Are the following present? 1.
hospitalization or antibiotics ... Community water-borne ... HIV infection or ... Consider empiric antibiotic ... Hospitalization required
Antibiotic classification refers to the categorization of antibiotics based on their chemical structure, mechanism of action,
Antibiotic classification ... treat bacterial infections ... 𝐢𝐧𝐜𝐥𝐮𝐝𝐞𝐬: 1. ... Imagine treatments ... #classification
Systemic Inflammatory Response Syndrome (SIRS) • Non-specific (infections vs non-infectious) • ≥2 of the following: o Temp >38°C or <36°C o HR >90 bpm o RR
Septic Shock • ... recognition & treatment ... (within 1 hour) ... Broad-spectrum antibiotics ... #sepsis #sirs #shock
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook Clinical Presentation + Progression:
Toxic Megacolon, Shock ... Epidemiology: • #1 ... post-ABx, but can be community-acquired ... Ileus, Megacolon, Shock ... 10 mg/kg IV x 1
Sepsis - Diagnosis and Management Life-threatening organ dysfunction caused by a dysregulated host response to infection SEPTIC SHOCK
host response to infection ... SEPTIC SHOCK is ... Patients w/ septic shock ... recognition and treatment ... broad spectrum antibiotics
Community Acquired Pneumonia (CAP) - Diagnosis and Management Pneumonia Signs/Symptoms: • Confusion/disorientation (LR + 1.9) • Cough
Community Acquired ... Egophony (May appear 1- ... 96.1% • Empiric antibiotic ... procalcitonin level Treatment ... #Pulmonary #Community
Sulfonamides - Antibiotics Class Overview BACTRIM/SEPTRA (TMP/SMX) - inhibit sequential steps in Folate synthesis --> bacteriostatic Spectrum: Wide
Sulfonamides - Antibiotics ... choice, both for treatment ... prophylaxis), Community-acquired ... MRSA Skin infections ... #Pharmacology #Antibiotics
CSF Penetration of Antimicrobials Despite the poor CSF penetration, beta-lactams have the most research documenting successful treatment
of community-acquired ... compared to other antibiotic ... classes. 1 only ... in clinical CNS infections ... of CNS infections
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