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Hemolytic Anemia - Hemolysis Diagnostic Workup

Infographic by: Howard Ong

#Hemolysis #Hemolytic #Anemia #Algorithm #MAHA #TTP #Diagnosis #Workup
Hemolytic Anemia ... - Hemolysis Diagnostic ... #Hemolytic #Anemia ... #TTP #Diagnosis ... #Workup #Hematology
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
Differential diagnosis ... microangiopathies (TMA) - TTP ... anemia" • HELLP ... Catastrophic APLS BCM IM ... #hematology #hemolysis
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Corpuscular Volume (MCV ... Algorithm Low ... • Bleeding • Hemolysis ... #MCV #Classification ... #Hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
Algorithmic Approach ... Diagnosis Framework ... , CKD • Hemolytic ... #MCV #Algorithm ... #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Corpuscular Volume (MCV ... - Differential Diagnosis ... Algorithm Decreased ... #Algorithm #Causes ... #Hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
- Differential Diagnosis ... Algorithm Extravascular ... anemia • ... • MAHA (TTP ... #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... Algorithm Blood ... Reticulocytes, MCV ... #Classification ... #Hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... Causes: • MAHA: TTP ... #classification ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Algorithm • Sickle ... thrombocytopenia - DIC, TTP ... #Diagnosis #Algorithm ... #workup #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... anemia Indirect ... tissue damage from ischemia ... impairment #TTP ... #Workup #Hematology