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CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... ) Clinical Manifestations ... Cerebrovascular Disease ... #CNS #neurology ... #rheumatology #
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... Diagnosis Algorithm ... (e.g. ... #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Volume (MCV) - Differential ... Diagnosis Algorithm ... • Secondary (e.g ... RA, SLE, PRV, Chronic ... #Causes #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Thrombocytopenia - Differential ... Diagnosis Algorithm ... Megakaryopoiesis • Aplastic Anemia ... Autoimmune • ITP • SLE ... #Causes #Hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Iron deficiency anemia ... anemia (sometimes ... Chemotherapy (e.g ... RBC #Morphology #differential ... #diagnosis #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
- Differential ... Diagnosis Framework ... aciduria, Drugs (e.g ... Non-megaloblastic: Liver disease ... #Diagnosis #hematology
Diffuse Acute Abdominal Pain (<72 hours) - Differential Diagnostic Algorithm
Look for surgical abdomen
Upper quadrant: R/O cardiac,
(<72 hours) - Differential ... Diagnostic Algorithm ... • Mesenteric ischemia ... (e.g., Diabetic ... • Sickle cell anemia
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Volume (MCV) - Differential ... Diagnosis Algorithm ... Increased Requirement (e.g ... • Liver Disease ... #Causes #Hematology
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Abnormality • SLE ... Iron deficiency anemia ... halt nail growth (e.g ... #dermatology #Differential ... #Diagnosis #Algorithm
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Microangiopathic hemolytic anemia ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia